Molecular weight (DA)
16kD
Immunogen
Synthesized peptide derived from part region of human protein. AA range 1-56
Specificity
NINJ1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009],
Function
function:Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.,induction:By nerve injury both in dorsal root ganglion neurons and in Schwann cells.,similarity:Belongs to the ninjurin family.,tissue specificity:Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.,
Protein name
Ninjurin-1 (Nerve injury-induced protein 1)
Human protein sequence Database
Q92982
Mouse protein sequence database
O70131
Rat protein sequence database
P70617
Cellular localization
[Ninjurin-1]: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptic cell membrane ; Multi-pass membrane protein .; [Secreted ninjurin-1]: Secreted .
Tissue expression
Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.
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