Molecular weight (DA)
69kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 50-130
Specificity
NET4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016],
Function
function:May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.,similarity:Contains 1 laminin N-terminal domain.,similarity:Contains 1 NTR domain.,similarity:Contains 3 laminin EGF-like domains.,subcellular location:Major component.,subunit:May form a homodimer.,tissue specificity:Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.,
Protein name
Netrin-4 (Beta-netrin) (Hepar-derived netrin-like protein)
Human protein sequence Database
Q9HB63
Mouse protein sequence database
Q9JI33
Rat protein sequence database
Cellular localization
Secreted, extracellular space, extracellular matrix, basement membrane . Major component.
Tissue expression
Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.
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