Molecular weight (DA)
133kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 370-450
Specificity
EHMT2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
Function
alternative products:Additional isoforms seem to exist,catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,caution:It is uncertain whether Met-1 or Met-21 is the initiator methionine.,caution:PubMed:11707778 reported that while NG36 and G9a were originally thought to derive from two separate genes, all G9A transcripts also contain the in frame coding sequence of NG36.,domain:The SET domain mediates interaction with WIZ.,function:Histone methyltransferase. Preferentially methylates 'Lys-9' of histone H3 and 'Lys-27' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also methylates histone H1.,PTM:Phosphoryla
Gene Name
EHMT2 BAT8 C6orf30 G9A KMT1C NG36
Protein name
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase
Fields
>>Lysine degradation;>>Metabolic pathways;>>Longevity regulating pathway
Human protein sequence Database
Q96KQ7
Mouse protein sequence database
Q9Z148
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Associates with euchromatic regions. Does not associate with heterochromatin.
Tissue expression
Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow.
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