Molecular weight (DA)
24kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 150-230
Specificity
DKK4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008],
Function
function:Inhibitor of Wnt signaling pathway.,PTM:Appears to be not glycosylated.,PTM:Can be proteolytically processed by a furin-like protease.,similarity:Belongs to the dickkopf family.,tissue specificity:Expressed in cerebellum, T-cells, esophagus and lung.,
Protein name
Dickkopf-related protein 4 (Dickkopf-4) (Dkk-4) (hDkk-4) [Cleaved into: Dickkopf-related protein 4 short form]
Fields
>>Wnt signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
Q9UBT3
Mouse protein sequence database
Q8VEJ3
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed in cerebellum, T-cells, esophagus and lung.
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