Molecular weight (DA)
39kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 230-310
Specificity
NAAA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
enzyme regulation:Stimulated by DTT and Nonidet P-40.,function:Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.,PTM:N-glycosylated. Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine.,similarity:Belongs to the acid ceramidase family.,tissue specificity:Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.,
Protein name
N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (Acid ceramidase-like protein) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid a
Human protein sequence Database
Q02083
Mouse protein sequence database
Q9D7V9
Rat protein sequence database
Q5KTC7
Cellular localization
Lysosome . Membrane ; Peripheral membrane protein .
Tissue expression
Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.
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