Molecular weight (DA)
56kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1-80
Specificity
VMAT2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011],
Function
function:Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.,online information:Vesicular monoamine transporter entry,similarity:Belongs to the major facilitator superfamily. Vesicular transporter family.,
Gene Name
SLC18A2 SVMT VMAT2
Protein name
Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)
Fields
>>Synaptic vesicle cycle;>>Serotonergic synapse;>>Dopaminergic synapse;>>Parkinson disease;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism
Human protein sequence Database
Q05940
Mouse protein sequence database
Q8BRU6
Rat protein sequence database
Q01827
Cellular localization
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Tissue expression
Brain,Platelet,Substantia nigra,Testis,
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