Molecular weight (DA)
66kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 150-230
Specificity
RYK Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms
Function
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Potential growth factor receptor protein tyrosine kinase.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 WIF domain.,tissue specificity:Observed in all the tissues examined.,
Protein name
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Fields
>>Wnt signaling pathway;>>Axon guidance
Human protein sequence Database
P34925
Mouse protein sequence database
Q01887
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type I membrane protein . Nucleus . Cytoplasm . In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. .
Tissue expression
Observed in all the tissues examined.
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