Molecular weight (DA)
87kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 190-270
Specificity
NADL2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
caution:Although related to the peptidase M28 family, it is probably inactive as an hydrolase due to lack of the conserved zinc-binding and active sites.,function:May be catalytically inactive.,miscellaneous:The gene maps to 3q26.31, a region associated with Cornelia de Lange syndrome. However, PubMed:15168106 failed to identify specific mutations in a panel of DNA samples from patients with Cornelia de Lange syndrome.,sequence caution:Contaminating sequence at the C-terminus.,similarity:Belongs to the peptidase M28 family. M28B subfamily.,tissue specificity:Expressed at higher level in kidney and placenta. In embryo, it is mainly confined to duodenal and stomach endoderm, mesonephros, metanephros and pancreas.,
Function
caution:Although related to the peptidase M28 family, it is probably inactive as an hydrolase due to lack of the conserved zinc-binding and active sites.,function:May be catalytically inactive.,miscellaneous:The gene maps to 3q26.31, a region associated with Cornelia de Lange syndrome. However, PubMed:15168106 failed to identify specific mutations in a panel of DNA samples from patients with Cornelia de Lange syndrome.,sequence caution:Contaminating sequence at the C-terminus.,similarity:Belongs to the peptidase M28 family. M28B subfamily.,tissue specificity:Expressed at higher level in kidney and placenta. In embryo, it is mainly confined to duodenal and stomach endoderm, mesonephros, metanephros and pancreas.,
Protein name
Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2)
Human protein sequence Database
Q58DX5
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type II membrane protein .
Tissue expression
Expressed at higher level in kidney and placenta. In embryo, it is mainly confined to duodenal and stomach endoderm, mesonephros, metanephros and pancreas.
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