Molecular weight (DA)
35kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 30-110
Specificity
TRML2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008],
Function
function:Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counterreceptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.,induction:Induced in CD4 T-cells by concanavalin A.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with CD276 and this interaction enhances T-cell activation.,tissue specificity:Detected in cultured B cells, T cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.,
Gene Name
TREML2 C6orf76 TLT2 UNQ6268/PRO20473
Protein name
Trem-like transcript 2 protein (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2)
Human protein sequence Database
Q5T2D2
Mouse protein sequence database
Q2LA85
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.
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