Molecular weight (DA)
167kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 270-350
Specificity
DISP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008],
Function
function:Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the dispatched family.,similarity:Contains 1 SSD (sterol-sensing) domain.,
Protein name
Protein dispatched homolog 1
Fields
>>Hedgehog signaling pathway
Human protein sequence Database
Q96F81
Mouse protein sequence database
Q3TDN0
Rat protein sequence database
Cellular localization
Membrane ; Multi-pass membrane protein .
Tissue expression
Colon,Kidney,Kidney epithelium,Muscle,Placenta,Testis,
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