Molecular weight (DA)
68kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 80-160
Specificity
PRLR Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011],
Function
domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoforms 4 and 6 are unable to transduce prolactin signaling.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Isoform 7.,subunit:Interacts with SMARCA1. Interacts with GH1.,tissue specificity:Expressed in breast, placenta, kidney, liver and pancreas.,
Protein name
Prolactin receptor (PRL-R)
Fields
>>Cytokine-cytokine receptor interaction;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>JAK-STAT signaling pathway;>>Prolactin signaling pathway
Human protein sequence Database
P16471
Mouse protein sequence database
Q08501
Rat protein sequence database
P05710
Cellular localization
Membrane ; Single-pass type I membrane protein .; [Isoform 7]: Secreted.
Tissue expression
Expressed in breast, placenta, kidney, liver and pancreas.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车