Molecular weight (DA)
52kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 270-350
Specificity
RTN4R Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008],
Function
function:Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.,online information:Nerve regrowth: nipped by a no-go - Issue 69 of April 2006,similarity:Belongs to the Nogo receptor family.,similarity:Contains 9 LRR (leucine-rich) repeats.,subunit:Homomultimer. Interacts with LINGO1.,tissue specificity:Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney not expressed in oligodendrocytes (white matter).,
Gene Name
RTN4R NOGOR UNQ330/PRO526
Protein name
Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor)
Human protein sequence Database
Q9BZR6
Mouse protein sequence database
Q99PI8
Rat protein sequence database
Q99M75
Cellular localization
Cell membrane ; Lipid-anchor, GPI-anchor . Membrane raft . Cell projection, dendrite . Cell projection, axon . Perikaryon . Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. .
Tissue expression
Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter).
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