Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Specificity
FCG3B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012],
Function
disease:The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides.,function:Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.,miscellaneous:Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The Phe-203 in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.,polymorphism:There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies
Gene Name
FCGR3B CD16B FCG3 FCGR3 IGFR3
Protein name
Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)
Fields
>>Phagosome;>>Osteoclast differentiation;>>Neutrophil extracellular trap formation;>>Natural killer cell mediated cytotoxicity;>>Fc gamma R-mediated phagocytosis;>>Leishmaniasis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Systemic lupus erythematosus
Human protein sequence Database
O75015
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Lipid-anchor, GPI-anchor . Secreted. Secreted after cleavage.
Tissue expression
Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.
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