Molecular weight (DA)
30kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 140-220
Specificity
CHODL Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011],
Function
online information:Chondrolectin,PTM:N-glycosylated.,similarity:Contains 1 C-type lectin domain.,tissue specificity:Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp of spleen.,
Gene Name
CHODL C21orf68 PRED12 UNQ872/PRO1890
Protein name
Chondrolectin (Transmembrane protein MT75)
Human protein sequence Database
Q9H9P2
Mouse protein sequence database
Q9CXM0
Rat protein sequence database
Cellular localization
Cytoplasm . Membrane ; Single-pass type I membrane protein .; [Isoform 2]: Endoplasmic reticulum . Endoplasmic reticulum membrane ; Single-pass type I membrane protein .; [Isoform 3]: Cytoplasm .
Tissue expression
Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp of spleen. B lymphocytes express isoform 2 only; peripheral blood T lymphocytes express isoform 3 only; granulocytes and monocytes express neither isoform 2 nor isoform 3. During development of T lymphocytes, bone marrow progenitor cells express isoform 2 only; thymocytes at different stages of maturation express predominantly isoform 2 and weakly isoform 3, and mature thymocytes express only isoform 2.
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