Molecular weight (DA)
61kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 481-530
Specificity
FLVC1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011],
Function
developmental stage:Down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization. Abundant in fetal liver.,function:Exports cytoplasmic heme. May be required to protect developing erythroid cells from heme toxicity. Causes susceptibility to FeLV-C in vitro.,similarity:Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.,tissue specificity:Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.,
Protein name
Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (hFLVCR)
Human protein sequence Database
Q9Y5Y0
Mouse protein sequence database
Rat protein sequence database
Cellular localization
[Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Mitochondrion membrane ; Multi-pass membrane protein .
Tissue expression
Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.
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