Molecular weight (DA)
49kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 211-260
Specificity
TBX20 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
T-box 20(TBX20) Homo sapiens This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
Function
disease:Defects in TBX20 are the cause of atrial septal defect type 4 (ASD4) [MIM:611363]. ASD4 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD4 patients show other heart abnormalities including defects in septation, chamber growth and valvulogenesis. ASD4 is not associated with defects in the cardiac conduction system or with non-cardiac abnormalities.,function:Probable transcriptional regulator involved in developmental processes.,similarity:Contains 1 T-box DNA-binding domain.,
Protein name
T-box transcription factor TBX20 (T-box protein 20)
Human protein sequence Database
Q9UMR3
Mouse protein sequence database
Q9ES03
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Fetal eye,
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