Molecular weight (DA)
41kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 180-260
Specificity
P2RY2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
purinergic receptor P2Y2(P2RY2) Homo sapiens The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013],
Function
function:Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Spleen, testis, kidney, liver, lung, heart and brain.,
Protein name
P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (Purinergic receptor)
Fields
>>Neuroactive ligand-receptor interaction;>>Inflammatory mediator regulation of TRP channels
Human protein sequence Database
P41231
Mouse protein sequence database
P35383
Rat protein sequence database
P41232
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Spleen, testis, kidney, liver, lung, heart and brain.
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