Molecular weight (DA)
84kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 280-360
Specificity
TSHR Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],
Function
alternative products:Additional isoforms seem to exist,disease:Autoantibodies directed against the TSH receptor are directly responsible for the pathogenesis and hyperthyroidism of Graves disease (GRD) [MIM:275000]. Antibody interaction with the TSH receptor results in an uncontrolled receptor stimulation.,disease:Defects in TSHR are a cause of hyperthyroidism [MIM:603372]. Various types are known: autosomal dominant non-autoimmune hyperthyroidism (ADNH); sporadic congenital hyperthyroidism (SCH); hyperthyroidism associated with autonomously functioning thyroid nodules (AFTN), toxic multinodular goiter (TMNG) and hyperfunctioning thyroid adenomas (HTA). TMNG encompasses a spectrum of different clinical entities, ranging from a single hyperfunctioning nodule within an enlarged thyroid, to multiple hyperfunctioning areas scattered throughout the gland. HTA are discrete encapsulated neoplas
Protein name
Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Thyroid hormone synthesis;>>Regulation of lipolysis in adipocytes;>>Autoimmune thyroid disease
Human protein sequence Database
P16473
Mouse protein sequence database
P47750
Rat protein sequence database
P21463
Cellular localization
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .
Tissue expression
Expressed in thyroide cells (at protein level) (PubMed:11847099). Expressed in the thyroid (PubMed:2610690).
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