Molecular weight (DA)
96kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 40-120
Specificity
GRM3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
glutamate metabotropic receptor 3(GRM3) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008],
Function
function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with GRASP.,
Gene Name
GRM3 GPRC1C MGLUR3
Protein name
Metabotropic glutamate receptor 3 (mGluR3)
Fields
>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>Glutamatergic synapse;>>Cocaine addiction
Human protein sequence Database
Q14832
Mouse protein sequence database
Q9QYS2
Rat protein sequence database
P31422
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车