Molecular weight (DA)
93kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 181-231
Specificity
MATR3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
matrin 3(MATR3) Homo sapiens This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013],
Function
function:May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.,similarity:Contains 1 matrin-type zinc finger.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Part of complex consisting of SFPQ, NONO and MATR3.,
Fields
>>Amyotrophic lateral sclerosis
Human protein sequence Database
P43243
Mouse protein sequence database
Q8K310
Rat protein sequence database
P43244
Cellular localization
Nucleus matrix.
Tissue expression
Amygdala,Brain,Epithelium,Fetal kidney,Hypothalamus,Liver,Retina,Skin,
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