Molecular weight (DA)
40kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 286-336
Specificity
ABI3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
Function
function:May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.,similarity:Belongs to the ABI family.,similarity:Contains 1 SH3 domain.,subcellular location:Colocalizes with PAK2 at leading edge of cells.,subunit:May interact with PAK1 and PAK2. Probably interacts with TARSH.,tissue specificity:Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.,
Protein name
ABI gene family member 3 (New molecule including SH3) (Nesh)
Human protein sequence Database
Q9P2A4
Mouse protein sequence database
Q8BYZ1
Rat protein sequence database
Cellular localization
Cytoplasm . Colocalizes with PAK2 at leading edge of cells.
Tissue expression
Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车