Molecular weight (DA)
21kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
PMVK Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011],
Function
catalytic activity:ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate.,induction:By sterol.,pathway:Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via mevalonic acid pathway; isopentenyl-PP from (R)-mevalonic acid: step 2/3.,subunit:Monomer.,tissue specificity:Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta, and lung.,
Protein name
Phosphomevalonate kinase (PMKase) (hPMK) (EC 2.7.4.2)
Fields
>>Terpenoid backbone biosynthesis;>>Metabolic pathways;>>Peroxisome
Human protein sequence Database
Q15126
Mouse protein sequence database
Q9D1G2
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol .
Tissue expression
Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung.
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