Molecular weight (DA)
14kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TFF2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008],
Function
function:Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.,similarity:Contains 2 P-type (trefoil) domains.,tissue specificity:Stomach.,
Protein name
Trefoil factor 2 (Spasmolysin) (Spasmolytic polypeptide) (SP)
Human protein sequence Database
Q03403
Mouse protein sequence database
Q03404
Rat protein sequence database
Q09030
Cellular localization
Secreted.
Tissue expression
Stomach.
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