Molecular weight (DA)
40kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 321-370
Specificity
GDF1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016],
Function
function:May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner.,function:May mediate cell differentiation events during embryonic development.,miscellaneous:This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame.,miscellaneous:This protein is produced by a bicistronic gene which also produces the LASS1 protein from a non-overlapping reading frame.,similarity:Belongs to the TGF-beta family.,similarity:Contains 1 TLC (TRAM/LAG1/CLN8) domain.,subcellular location:Isoform 1 may recycle from the Golgi to the endoplasmic reticulum.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in the brain.,
Protein name
Embryonic growth/differentiation factor 1 (GDF-1)
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
P27539
Mouse protein sequence database
P20863
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed in the brain.
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