Molecular weight (DA)
13kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 1-50
Specificity
GON2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
gonadotropin releasing hormone 2(GNRH2) Homo sapiens This gene encodes a secreted peptide hormone and member of the gonadotropin-releasing hormone (GnRH) family of proteins. The encoded protein regulates reproductive function by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The encoded protein may inhibit endometrial, ovarian, prostate, and breast cancer cell proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],
Function
alternative products:Experimental confirmation may be lacking for some isoforms,function:Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.,similarity:Belongs to the GnRH family.,tissue specificity:Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.,
Protein name
Progonadoliberin-2 (Progonadoliberin II) [Cleaved into: Gonadoliberin-2 (Gonadoliberin II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II) (Luteinizing hormone-releasing hormone II) (LH-R
Fields
>>Neuroactive ligand-receptor interaction;>>GnRH signaling pathway;>>GnRH secretion
Human protein sequence Database
O43555
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.
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