Molecular weight (DA)
30kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MARE3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008],
Function
domain:Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.,function:May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.,similarity:Belongs to the MAPRE family.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 EB1 C-terminal domain.,subcellular location:Associated with the microtubule network.,subunit:Interacts with APC2 (By similarity). Interacts with DCTN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin.,tissue specificity:Predominantly expressed in brain and muscle.,
Protein name
Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3)
Human protein sequence Database
Q9UPY8
Mouse protein sequence database
Q6PER3
Rat protein sequence database
Q5XIT1
Cellular localization
Cytoplasm, cytoskeleton . Associated with the microtubule network. Detected at the plus end of microtubules. .
Tissue expression
Predominantly expressed in brain and muscle.
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