Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DERL3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
derlin 3(DERL3) Homo sapiens The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008],
Function
function:Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.,induction:Up-regulated in response to ER stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).,similarity:Belongs to the derlin family.,subunit:Forms homo- and heterooligomers with DERL2 and, to a lesser extent, with DERL1. Interacts with VCP and EDEM1.,tissue specificity:Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.,
Gene Name
DERL3 C22orf14 DER3 LLN2
Protein name
Derlin-3 (Degradation in endoplasmic reticulum protein 3) (DERtrin-3) (Der1-like protein 3)
Fields
>>Protein processing in endoplasmic reticulum
Human protein sequence Database
Q96Q80
Mouse protein sequence database
Q9D8K3
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue expression
Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.
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