Molecular weight (DA)
140kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RGRF1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009],
Function
domain:The DH (DBL-homology) domain mediates interaction with RASGRF2.,function:Promotes the exchange of Ras-bound GDP by GTP.,PTM:Ubiquitinated.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 IQ domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 2 PH domains.,subunit:Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability.,
Gene Name
RASGRF1 CDC25 GNRP GRF1
Protein name
Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25)
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Focal adhesion
Human protein sequence Database
Q13972
Mouse protein sequence database
P27671
Rat protein sequence database
P28818
Cellular localization
intracellular,cytosol,plasma membrane,growth cone,neuron projection,
Tissue expression
Brain,Thalamus,
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