Molecular weight (DA)
75kD
Immunogen
Synthesized peptide derived from human UGT1A9 AA range: 390-440
Specificity
This antibody detects endogenous levels of UGT1A9 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.11% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008],
Function
alternative products:A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues,alternative products:A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues,catalytic activity:UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in UGT1A1 are the cause of Crigler-Najjar syndrome type I (CN-I) [MIM:218800]. CN-I patients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN-I inheritance is autosomal recessive.,disease:Defects in UGT1A1 are the cause of Crigler-Najjar syn
Gene Name
UGT1A9 GNT1 UGT1
Other name
UDP-glucuronosyltransferase 1-9 (UDPGT 1-9) (UGT1*9) (UGT1-09) (UGT1.9) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-I) (UGT-1I) (UGT1I) (UDP-glucuronosyltransferase 1A9) (lugP4)
Fields
>>Pentose and glucuronate interconversions;>>Ascorbate and aldarate metabolism;>>Steroid hormone biosynthesis;>>Retinol metabolism;>>Porphyrin metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Drug metabolism - cytochrome P450;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Bile secretion;>>Chemical carcinogenesis - DNA adducts;>>Chemical carcinogenesis - receptor activation
Human protein sequence Database
O60656
Mouse protein sequence database
Q62452
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass membrane protein .
Tissue expression
[Isoform 1]: Expressed in liver, kidney, colon, esophagus and small intestine. ; [Isoform 2]: Expressed in liver, kidney, colon, esophagus and small intestine.
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