Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human DND1 AA range: 94-144
Specificity
This antibody detects endogenous levels of DND1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.33% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010],
Function
function:May play a role during primordial germ cell (PGC) development. However, does not seem to be essential for PGC migration.,similarity:Contains 2 RRM (RNA recognition motif) domains.,
Other name
Dead end protein homolog 1 (RNA-binding motif, single-stranded-interacting protein 4)
Human protein sequence Database
Q8IYX4
Mouse protein sequence database
Q6VY05
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). .
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