Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human PNMA1 AA range: 14-64
Specificity
This antibody detects endogenous levels of PNMA1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.39% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. [provided by RefSeq, Feb 2014],
Function
miscellaneous:Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.,similarity:Belongs to the PNMA family.,subcellular location:In tumor cells, it is cytoplasmic.,tissue specificity:Testis and brain specific. In some patients suffering from cancers, it is also specifically expressed by the paraneoplastic tumor cells.,
Other name
Paraneoplastic antigen Ma1 (37 kDa neuronal protein) (Neuron- and testis-specific protein 1)
Human protein sequence Database
Q8ND90
Mouse protein sequence database
Q8C1C8
Rat protein sequence database
Q8VHZ4
Cellular localization
Nucleus, nucleolus . In tumor cells, it is cytoplasmic.
Tissue expression
Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.
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