Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human MBNL3 AA range: 184-234
Specificity
This antibody detects endogenous levels of MBNL3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.58% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009],
Function
function:Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.,similarity:Belongs to the muscleblind family.,similarity:Contains 4 C3H1-type zinc fingers.,subcellular location:Greater concentration in the nucleus. In both myotonic dystrophy 1 (DM1) and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.,tissue specificity:Highly expressed in the placenta.,
Gene Name
MBNL3 CHCR MBLX39 MBXL
Other name
Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR)
Human protein sequence Database
Q9NUK0
Mouse protein sequence database
Q8R003
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
Tissue expression
Highly expressed in the placenta.
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