Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human T3HPD AA range: 11-61
Specificity
This antibody detects endogenous levels of T3HPD at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.62% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a dehydratase that converts trans-3-hydroxy-L-proline to delta(1)-pyrroline-2-carboxylate. This enzyme may function to degrade dietary proteins that contain trans-3-hydroxy-L-proline as well as other proteins such as collagen IV. The encoded protein can be converted to an epimerase by changing a threonine to a cysteine at a catalytic site. [provided by RefSeq, Sep 2016],
Function
catalytic activity:L-proline = D-proline.,function:Catalyzes the interconversion of L- and D-proline.,miscellaneous:In contrast to the T.cruzi enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue. The high conservation of the protein nevertheless suggests that it is nevertheless active.,similarity:Belongs to the proline racemase family.,subunit:Homodimer.,
Gene Name
L3HYPDH C14orf149
Other name
Trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) (Trans-3-hydroxy-l-proline dehydratase)
Fields
>>Arginine and proline metabolism;>>Metabolic pathways
Human protein sequence Database
Q96EM0
Mouse protein sequence database
Q9CXA2
Rat protein sequence database
Tissue expression
Ubiquitously expressed.
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