Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human STX5 AA range: 233-283
Specificity
This antibody detects endogenous levels of STX5 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.74% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],
Function
function:Mediates endoplasmic reticulum to Golgi transport (By similarity). Golgi apparatus membrane; Single-pass type IV membrane protein .,similarity:Belongs to the syntaxin family.,similarity:Contains 1 t-SNARE coiled-coil homology domain.,subunit:Part of a ternary complex containing STX5A, NSFL1C and VCP. Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2 and YKT6.,
Fields
>>SNARE interactions in vesicular transport
Human protein sequence Database
Q13190
Mouse protein sequence database
Q8K1E0
Rat protein sequence database
Q08851
Cellular localization
Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type IV membrane protein . Golgi apparatus membrane . Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. .
Tissue expression
B-cell,Heart,Kidney,Umbilical cord blood,Uterus,
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