Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human VGLU1 AA range: 488-538
Specificity
This antibody detects endogenous levels of VGLU1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.79% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008],
Function
function:Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.,similarity:Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.,tissue specificity:Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.,
Gene Name
SLC17A7 BNPI VGLUT1
Other name
Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7)
Fields
>>Synaptic vesicle cycle;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Nicotine addiction
Human protein sequence Database
Q9P2U7
Mouse protein sequence database
Q3TXX4
Rat protein sequence database
Q62634
Cellular localization
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
Tissue expression
Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.
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