Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human ARI3B AA range: 459-509
Specificity
This antibody detects endogenous levels of ARI3B at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.83% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008],
Function
function:Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.,similarity:Contains 1 ARID domain.,subunit:Heterodimer with ARID3A. Interacts with unphosphorylated RB1.,tissue specificity:Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K562 erythrocytic leukemia cells (at protein level).,
Gene Name
ARID3B BDP DRIL2
Other name
AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein)
Human protein sequence Database
Q8IVW6
Mouse protein sequence database
Q9Z1N7
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K-562 erythrocytic leukemia cell line (at protein level).
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