Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human S2610 AA range: 295-345
Specificity
This antibody detects endogenous levels of S2610 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.111% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
caution:According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.,domain:The guanine nucleotide exchange activity is autoinhibited by the PH domain.,function:Chloride/bicarbonate exchanger.,function:May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain
Other name
Solute carrier family 26 member 10
Human protein sequence Database
Q8NG04
Mouse protein sequence database
Q5EBI0
Rat protein sequence database
Cellular localization
Membrane ; Multi-pass membrane protein .
Tissue expression
Brain,Cerebellum,Testis,
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