Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human SYCM AA range: 95-145
Specificity
This antibody detects endogenous levels of SYCM at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.121% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. [provided by RefSeq, Mar 2015],
Function
catalytic activity:ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the class-I aminoacyl-tRNA synthetase family.,
Gene Name
CARS2 OK/SW-cl.10
Other name
Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)
Fields
>>Aminoacyl-tRNA biosynthesis
Human protein sequence Database
Q9HA77
Mouse protein sequence database
Q8BYM8
Rat protein sequence database
Cellular localization
Mitochondrion matrix .
Tissue expression
Colon adenocarcinoma,Lung,Lymph node,Mammary gland,Salivary gland,Testis,
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