Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human PGTA AA range: 312-362
Specificity
This antibody detects endogenous levels of PGTA at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.146% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
catalytic activity:Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.,cofactor:Binds 1 zinc ion per dimer.,enzyme regulation:The enzymatic reaction requires the aid of a Rab escort protein (also called component A).,function:Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.,similarity:Belongs to the protein prenyltransferase subunit alpha family.,similarity:Contains 6 PFTA repeats.,subunit:Heterodimer of an alpha and a beta subunit, collectively called component B.,
Other name
Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)
Human protein sequence Database
Q92696
Mouse protein sequence database
Q9JHK4
Rat protein sequence database
Q08602
Cellular localization
plasma membrane,Rab-protein geranylgeranyltransferase complex,
Tissue expression
Fetal brain,Lung,Thymus,Tongue,