Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human AF9 AA range: 328-378
Specificity
This antibody detects endogenous levels of AF9 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.153% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
disease:A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with MLL/HRX. The result is a rogue activator protein.,similarity:Contains 1 YEATS domain.,subunit:Interacts with BCOR. Interacts with CBX8.,
Gene Name
MLLT3 AF9 YEATS3
Other name
Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
Fields
>>Viral life cycle - HIV-1;>>Transcriptional misregulation in cancer
Human protein sequence Database
P42568
Mouse protein sequence database
A2AM29
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Colocalizes with acylated histone H3 (PubMed:25417107, PubMed:27105114). Colocalizes with histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). .
Tissue expression
Enriched in undifferentiated hematopoietic stem cells in fetal liver, cord blood and bone marrow.
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