Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human CR1L AA range: 45-95
Specificity
This antibody detects endogenous levels of CR1L at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.163% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 8 Sushi (CCP/SCR) domains.,subcellular location:Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.,subunit:Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3).,tissue specificity:Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue.,
Other name
Complement component receptor 1-like protein (Complement C4b-binding protein CR-1-like protein)
Fields
>>Complement and coagulation cascades;>>Neutrophil extracellular trap formation;>>Hematopoietic cell lineage;>>Legionellosis;>>Leishmaniasis;>>Malaria;>>Tuberculosis
Human protein sequence Database
Q2VPA4
Mouse protein sequence database
Q64735
Rat protein sequence database
Q63135
Cellular localization
Cytoplasm . Membrane . Secreted . Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.
Tissue expression
Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue.
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