Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human MEX3B AA range: 434-484
Specificity
This antibody detects endogenous levels of MEX3B at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.168% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012],
Function
domain:Binds RNA through its KH domains.,function:RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.,PTM:Phosphorylated.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 2 KH domains.,subcellular location:Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.,tissue specificity:Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.,
Gene Name
MEX3B KIAA2009 RKHD3 RNF195
Other name
RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195)
Human protein sequence Database
Q6ZN04
Mouse protein sequence database
Q69Z36
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Cytoplasm, P-body . Cytoplasmic granule . Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.
Tissue expression
Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.
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