Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from human DPYL3 AA range: 240-290
Specificity
This antibody detects endogenous levels of DPYL3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.179% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subcellular location:Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.,tissue specificity:Mainly in heart and skeletal muscle. Also expressed strongly in fetal brain and spinal cord.,
Gene Name
DPYSL3 CRMP4 DRP3 ULIP ULIP1
Other name
Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1)
Human protein sequence Database
Q14195
Mouse protein sequence database
Q62188
Rat protein sequence database
Q62952
Cellular localization
Cytoplasm . Cell projection, growth cone . Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. .
Tissue expression
Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
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