Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human AL2CL AA range: 606-656
Specificity
This antibody detects endogenous levels of AL2CL at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.222% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.,similarity:Contains 1 VPS9 domain.,similarity:Contains 8 MORN repeats.,subcellular location:Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.,subunit:Homodimer. Forms a heteromeric complex with ALS2 (By similarity). Interacts with ALS2 and RAB5A.,tissue specificity:Expressed in heart and kidney.,
Other name
ALS2 C-terminal-like protein
Human protein sequence Database
Q60I27
Mouse protein sequence database
Q60I26
Rat protein sequence database
Cellular localization
Cytoplasm . Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
Tissue expression
Expressed in heart and kidney.
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