Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human SAFB2 AA range: 737-787
Specificity
This antibody detects endogenous levels of SAFB2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.226% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016],
Function
function:Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 1 SAP domain.,subunit:Interacts with SAFB/SAFB1 and SCAM1.,tissue specificity:Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.,
Other name
Scaffold attachment factor B2 (SAF-B2)
Human protein sequence Database
Q14151
Mouse protein sequence database
Q80YR5
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus.
Tissue expression
Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.
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