Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human POK17 AA range: 351-401
Specificity
This antibody detects endogenous levels of POK17 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.229% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,catalytic activity:Endonucleolytic cleavage to 5'-phosphomonoester.,domain:The LPQG and YXDD motifs are catalytically important and conserved among many retroviruses.,function:Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.,miscellaneous:Exact N-terminus of this protein has not been formally described.,miscellaneous:This protein is synthesized as Gag-Pr
Other name
HERV-K_11q22.1 provirus ancestral Pol protein [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
Human protein sequence Database
P63136
Mouse protein sequence database
Rat protein sequence database
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