Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human FBX10 AA range: 8-58
Specificity
This antibody detects endogenous levels of FBX10 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.238% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008],
Function
function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 17 PbH1 repeats.,subunit:Directly interacts with SKP1A and CUL1.,
Other name
F-box only protein 10
Human protein sequence Database
Q9UK96
Mouse protein sequence database
Q7TQF2
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Brain,PCR rescued clones,Spleen,
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