Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human XYLT1 AA range: 312-362
Specificity
This antibody detects endogenous levels of XYLT1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.253% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009],
Function
catalytic activity:Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate.,cofactor:Divalent cations.,function:Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.,miscellaneous:Activity is strongly reduced in seminal plasma of unfertile men.,online information:GlycoGene database,pathway:Glycan metabolism; chondroitin sulfate biosynthesis.,pathway:Glycan metabolism; heparan sulfate biosynthesis.,PTM:Contains 7 disulfide bonds.,PTM:N-glycosylated.,similarity:Belongs to the glycosyltransferase 14 family. XylT subfamily.,subcellular location:Some fraction is also found in the extracellular space together with chond
Other name
Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)
Fields
>>Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate;>>Glycosaminoglycan biosynthesis - heparan sulfate / heparin;>>Metabolic pathways
Human protein sequence Database
Q86Y38
Mouse protein sequence database
Q811B1
Rat protein sequence database
Q9EPI1
Cellular localization
Golgi apparatus membrane ; Single-pass type II membrane protein . Secreted . Detected predominantly in the Golgi apparatus. .
Tissue expression
Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle.
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