Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human KINH AA range: 64-114
Specificity
This antibody detects endogenous levels of KINH at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.266% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,function:Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.,similarity:Belongs to the kinesin-like protein family.,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subcellular location:Uniformly distributed between soma and neurites in hippocampal neurons.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 (By similarity). Interacts with
Other name
Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)
Fields
>>Endocytosis;>>Dopaminergic synapse;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Salmonella infection;>>Non-small cell lung cancer
Human protein sequence Database
P33176
Mouse protein sequence database
Q61768
Rat protein sequence database
Q2PQA9
Cellular localization
Cytoplasm, cytoskeleton . Cytolytic granule membrane . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Uniformly distributed between soma and neurites in hippocampal neurons. .
Tissue expression
Muscle,Placenta,Uterus,
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