Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human PP6R2 AA range: 59-109
Specificity
This antibody detects endogenous levels of PP6R2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.273% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Protein phosphatase regulatory subunits, such as SAPS2, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS2 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010],
Function
function:Regulatory subunit of protein phospatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.,similarity:Belongs to the SAPS family.,subunit:Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28.,tissue specificity:Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta.,
Gene Name
PPP6R2 KIAA0685 PP6R2 SAPS2
Other name
Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2)
Human protein sequence Database
O75170
Mouse protein sequence database
Q8R3Q2
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta.
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